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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure

Fig. 6

Microglial activation in retina from a model of sustained ocular hypertension. a Weekly IOP measurements from mice injected with magnetic beads (red) or saline control (black; 1-way RM ANOVA with Sidak’s MC test). b The IOP integral (right) expressed as summed mmHg days exposure over baseline IOP, for bead and saline-injected eyes (unpaired Student’s t test). c Representative staining for Iba1 in cryosections 7 weeks after injection with saline (top) or beads (bottom), suggesting sustained elevation of IOP also induces changes in the microglial phenotype emblematic of activation. Bar = 50 μm. d Quantification of a 5-μm area surrounding the soma indicates significant elevation of Iba1 intensity per cell in bead-injected mice (unpaired Student’s t test). All data from Ctrl: n = 4 retinae from 3 mice, Bead: n = 3 retinae from 3 mice. Statistical significance shown as *p < 0.05

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Journal of Neuroinflammation

ISSN: 1742-2094