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Table 2 Ratios of pro/anti-inflammatory cytokines suggest both types of cytokines are largely upregulated in the ventral hippocampus of old versus young C57BL/6J mice to the same extent

From: Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions

Ratioa Young mean Young SEM Old mean Old SEM Student’s T test or rank sum Raw P value FDR-P value
IL-1α/IL-10 1.00 0.05 1.30 0.18 Failed EV: T(7,7)=39.00 0.0973 0.37537
IL-1β/IL-10 1.01 0.06 1.25 0.13 t(12)=-1.705318 0.1139 0.38428
IL-2/IL-10 1.04 0.12 0.85 0.08 t(12)=1.317512 0.2123 0.4776
IL-6/IL-10 1.03 0.08 1.09 0.12 t(12)=-0.369068 0.7185 0.84346
IL-12p40/IL-10 1.04 0.09 1.09 0.09 t(12)=-0.391351 0.7024 0.90308
IL-12p70/IL-10 1.05 0.12 1.09 0.14 t(12)=-0.232436 0.8201 0.88573
G-CSF/IL-10 1.01 0.10 0.95 0.08 t(12)=0.469474 0.6471 0.87365
IFNγ/IL-10 1.03 0.12 0.80 0.14 t(12)=1.204295 0.2517 0.48541
MIP-1α/IL-10 1.13 0.29 0.91 0.10 Failed normality: T(7,7)=55.00 0.8048 0.90538
TNFα/IL-10 1.02 0.05 1.53 0.28 Failed normality: T(7,7)=37.00 0.0530 0.28636
IL-1α/IL-4 1.00 0.18 1.06 0.20 t(12)=-0.21 0.8382 0.87044
IL-1β/IL-4 1.00 0.19 0.98 0.15 t(12)=0.10 0.9183 0.9183
IL-2/IL-4 0.99 0.20 0.66 0.11 t(12)=1.46 0.1727 0.4239
IL-6/IL-4 1.02 0.17 0.87 0.16 t(12)=0.64 0.5300 0.795
IL-12p40/IL-4 0.99 0.15 0.86 0.13 t(12)=0.64 0.5400 0.76737
IL-12p70/IL-4 0.96 0.15 0.87 0.17 t(12)=0.38 0.7100 0.87136
G-CSF/IL-4 1.07 0.22 0.76 0.13 t(12)=1.30 0.2200 0.45692
IFNg/IL-4 1.02 0.26 0.60 0.10 t(12)=1.59 0.1400 0.42
MIP-1α/IL-4 0.92 0.09 0.68 0.08 t(12)=2.06 0.0636 0.2862
TNFα/IL-4 0.99 0.16 1.22 0.26 t(12)=-0.72 0.4844 0.76934
IL-1β/IL6 1.00 0.06 1.19 0.10 Failed normality: T(7,7)=16.0 0.3200 0.576
GM-CSF/IL-6 1.01 0.10 0.62 0.12 t(12)=2.563987 0.0248 0.33506
IFNγ/IL-6 1.01 0.11 0.76 0.13 t(12)=1.451187 0.1724 0.46538
IL-1α/IL-13 1.01 0.06 0.76 0.09 t(12)=2.445990 0.0308 0.27736
IL-1β/IL-13 1.02 0.05 0.74 0.05 t(12)=3.973891 0.0018 0.04987
MIP-1α/IL-13 1.15 0.33 0.58 0.11 Failed normality: T(7,7)=68.0 0.0530 0.35775
TNFα/IL-13 1.05 0.11 0.89 0.12 t(12)=1.02 0.3286 0.55451
  1. EV equal variance
  2. aPairings of pro- vs anti-inflammatory cytokines based on https://www.sinobiological.com/resource/cytokines/all-anti-inflammatory-cytokines (accessed 04/05/21). Note that 1 young subject expressed no IL-4; therefore, data from this subject could not be expressed as a ratio. Thus, n=7/age for all except for IL-4 ratios where n=6 for young