Skip to main content

Table 2 Ratios of pro/anti-inflammatory cytokines suggest both types of cytokines are largely upregulated in the ventral hippocampus of old versus young C57BL/6J mice to the same extent

From: Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions

Ratioa

Young mean

Young SEM

Old mean

Old SEM

Student’s T test or rank sum

Raw P value

FDR-P value

IL-1α/IL-10

1.00

0.05

1.30

0.18

Failed EV: T(7,7)=39.00

0.0973

0.37537

IL-1β/IL-10

1.01

0.06

1.25

0.13

t(12)=-1.705318

0.1139

0.38428

IL-2/IL-10

1.04

0.12

0.85

0.08

t(12)=1.317512

0.2123

0.4776

IL-6/IL-10

1.03

0.08

1.09

0.12

t(12)=-0.369068

0.7185

0.84346

IL-12p40/IL-10

1.04

0.09

1.09

0.09

t(12)=-0.391351

0.7024

0.90308

IL-12p70/IL-10

1.05

0.12

1.09

0.14

t(12)=-0.232436

0.8201

0.88573

G-CSF/IL-10

1.01

0.10

0.95

0.08

t(12)=0.469474

0.6471

0.87365

IFNγ/IL-10

1.03

0.12

0.80

0.14

t(12)=1.204295

0.2517

0.48541

MIP-1α/IL-10

1.13

0.29

0.91

0.10

Failed normality: T(7,7)=55.00

0.8048

0.90538

TNFα/IL-10

1.02

0.05

1.53

0.28

Failed normality: T(7,7)=37.00

0.0530

0.28636

IL-1α/IL-4

1.00

0.18

1.06

0.20

t(12)=-0.21

0.8382

0.87044

IL-1β/IL-4

1.00

0.19

0.98

0.15

t(12)=0.10

0.9183

0.9183

IL-2/IL-4

0.99

0.20

0.66

0.11

t(12)=1.46

0.1727

0.4239

IL-6/IL-4

1.02

0.17

0.87

0.16

t(12)=0.64

0.5300

0.795

IL-12p40/IL-4

0.99

0.15

0.86

0.13

t(12)=0.64

0.5400

0.76737

IL-12p70/IL-4

0.96

0.15

0.87

0.17

t(12)=0.38

0.7100

0.87136

G-CSF/IL-4

1.07

0.22

0.76

0.13

t(12)=1.30

0.2200

0.45692

IFNg/IL-4

1.02

0.26

0.60

0.10

t(12)=1.59

0.1400

0.42

MIP-1α/IL-4

0.92

0.09

0.68

0.08

t(12)=2.06

0.0636

0.2862

TNFα/IL-4

0.99

0.16

1.22

0.26

t(12)=-0.72

0.4844

0.76934

IL-1β/IL6

1.00

0.06

1.19

0.10

Failed normality: T(7,7)=16.0

0.3200

0.576

GM-CSF/IL-6

1.01

0.10

0.62

0.12

t(12)=2.563987

0.0248

0.33506

IFNγ/IL-6

1.01

0.11

0.76

0.13

t(12)=1.451187

0.1724

0.46538

IL-1α/IL-13

1.01

0.06

0.76

0.09

t(12)=2.445990

0.0308

0.27736

IL-1β/IL-13

1.02

0.05

0.74

0.05

t(12)=3.973891

0.0018

0.04987

MIP-1α/IL-13

1.15

0.33

0.58

0.11

Failed normality: T(7,7)=68.0

0.0530

0.35775

TNFα/IL-13

1.05

0.11

0.89

0.12

t(12)=1.02

0.3286

0.55451

  1. EV equal variance
  2. aPairings of pro- vs anti-inflammatory cytokines based on https://www.sinobiological.com/resource/cytokines/all-anti-inflammatory-cytokines (accessed 04/05/21). Note that 1 young subject expressed no IL-4; therefore, data from this subject could not be expressed as a ratio. Thus, n=7/age for all except for IL-4 ratios where n=6 for young
Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094