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Table 2 Comparison between the controls and the patients with stroke (at baseline before thrombectomy)

From: Plasma neurofilament light chain level predicts outcomes in stroke patients receiving endovascular thrombectomy

  Control (n = 14) Stroke (n = 60) P value
Age 66.0±1.41 71.2±11.8 0.001
Male sex 8 (57.1%) 34 (56.7%) 0.97
Hypertension 12 (85.7) 39 (65.0%) 0.20
Diabetes mellitus 5 (35.7%) 22 (36.7%) 0.95
Hyperlipidemia 10 (71.4%) 33 (55.0%) 0.37
Atrial fibrillation 5 (35.7%) 37 (61.7%) 0.13
NfL pg/ml 9.44 (7.73, 13.0) 33.3 (19.6, 88.9) 0.046
GFAP pg/mL 82.9 (55.3, 114.0) 238.8 (146.0, 330.5) 0.015
Tau pg/mL 1.62 (1.12, 2.00) 1.71 (0.97, 2.87) 0.26
UCHL1 pg/mL 7.30 (4.13, 13.5) 83.6 (64.8, 107.6) <0.001
Log NfL 2.33±0.37 3.74±1.17 <0.001
Log GFAP 4.35±0.50 5.63±0.97 <0.001
Log Tau 0.31±0.75 0.38±1.12 0.61
Log UCHL1 1.95±0.91 4.41±0.40 <0.001
  1. The count and continuous variables are expressed as numbers (percentages) and as mean ± standard deviations, respectively, except for the raw biomarker data, which are presented as medians (first quartile, third quartile) because of their nonnormal distributions. The Mann–Whitney U test was used for the raw biomarker data, a t test was used for the natural log–transformed biomarkers, and the P values for biomarkers were adjusted for age