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Table 4 Associations between biomarker levels and clinical outcomes

From: Plasma neurofilament light chain level predicts outcomes in stroke patients receiving endovascular thrombectomy

  Time points Death or disability (n=28) Any hemorrhagic transformation (n=20) Parenchymal hemorrhage (n=6)
   OR (95% CI) OR (95% CI) OR (95% CI)
NfL T1 2.05 (1.03–4.08)* 0.64 (0.35–1.17) 0.94 (0.45–1.98)
T2 2.05 (1.05–4.01)* 0.65 (0.37–1.16) 0.96 (0.48–1.94)
T3 3.94 (1.44–10.79)* 0.74 (0.39–1.42) 1.35 (0.64–2.84)
All 2.22 (1.27–3.88) 0.67 (0.40–1.15) 1.05 (0.44–2.55)
GFAP T1 1.42 (0.73–2.78) 1.01 (0.53–1.91) 0.90 (0.36–2.26)
T2 1.49 (0.75–2.97) 1.19 (0.64–2.24) 1.21 (0.55–2.70)
T3 1.28 (0.84–1.95) 2.39 (1.214.72)* 2.51 (1.185.34)
All 1.18 (0.91–1.52) 1.21 (0.96–1.53) 1.29 (0.97–1.70)
Tau T1 1.19 (0.66–2.14) 0.48 (0.250.93) 0.57 (0.29–1.11)
T2 1.13 (0.50–2.55) 0.43 (0.200.95) 0.73 (0.30–1.78)
T3 1.14 (0.70–1.86) 0.85 (0.53–1.39) 1.10 (0.57–2.14)
All 1.11 (0.76–1.63) 0.63 (0.38–1.07) 0.79 (0.46–1.36)
UCHL1 T1 0.83 (0.19–3.70) 0.84 (0.16–4.49) 0.22 (0.03–1.85)
T2 2.60 (0.53–12.64) 1.04 (0.20–5.35) 0.60 (0.08–4.46)
T3 2.73 (0.88–8.51) 2.64 (0.83–8.41) 5.98 (1.3127.24)
All 1.76 (0.59–5.23) 1.38 (0.53–3.61) 1.56 (0.56–4.31)
  1. Covariates adjusted for in the logistic regression models were age, sex, NIHSS score, atrial fibrillation, and successful recanalization for death or disability; age, sex, hypertension, and NIHSS score for any hemorrhagic transformation; and none for parenchymal hemorrhage. Generalized linear mixed models were employed to model all of the time points together. Bold type indicates significant results (P < 0.05). *False discovery rate–adjusted P < 0.05