Table 4 Associations between biomarker levels and clinical outcomes

NfL

T1

2.05 (1.03–4.08)*

0.64 (0.35–1.17)

0.94 (0.45–1.98)

T2

2.05 (1.05–4.01)*

0.65 (0.37–1.16)

0.96 (0.48–1.94)

T3

3.94 (1.44–10.79)*

0.74 (0.39–1.42)

1.35 (0.64–2.84)

All

2.22 (1.27–3.88)

0.67 (0.40–1.15)

1.05 (0.44–2.55)

GFAP

T1

1.42 (0.73–2.78)

1.01 (0.53–1.91)

0.90 (0.36–2.26)

T2

1.49 (0.75–2.97)

1.19 (0.64–2.24)

1.21 (0.55–2.70)

T3

1.28 (0.84–1.95)

2.39 (1.21–4.72)*

2.51 (1.18–5.34)

All

1.18 (0.91–1.52)

1.21 (0.96–1.53)

1.29 (0.97–1.70)

Tau

T1

1.19 (0.66–2.14)

0.48 (0.25–0.93)

0.57 (0.29–1.11)

T2

1.13 (0.50–2.55)

0.43 (0.20–0.95)

0.73 (0.30–1.78)

T3

1.14 (0.70–1.86)

0.85 (0.53–1.39)

1.10 (0.57–2.14)

All

1.11 (0.76–1.63)

0.63 (0.38–1.07)

0.79 (0.46–1.36)

UCHL1

T1

0.83 (0.19–3.70)

0.84 (0.16–4.49)

0.22 (0.03–1.85)

T2

2.60 (0.53–12.64)

1.04 (0.20–5.35)

0.60 (0.08–4.46)

T3

2.73 (0.88–8.51)

2.64 (0.83–8.41)

5.98 (1.31–27.24)

All

1.76 (0.59–5.23)

1.38 (0.53–3.61)

1.56 (0.56–4.31)