Skip to main content
Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Kynurenine pathway in post-mortem prefrontal cortex and cerebellum in schizophrenia: relationship with monoamines and symptomatology

Fig. 5

Correlations of the kynurenine pathway with monoamine pathway and SZ symptomatology. A Differences in monoamine pathway elements between control (n = 14) and schizophrenia group (n = 15) in the post-mortem prefrontal cortex by ultra-high-performance liquid chromatography-tandem mass spectrometry. One outlier was detected for 3-OMD, MHPG and 3OHTrp in the control group and one in the schizophrenia group for 3-OHTrp and therefore excluded from the analysis. Results were expressed as pmol/gramme of tissue. Statistical analysis was performed using unpaired t test or Mann-Whitney test (p < 0.05). B Schematic representation of the significant interactions between dopaminergic, noradrenergic and serotoninergic pathway elements in the schizophrenia group (n = 15) and final product elements from the kynurenine pathway in the cerebellum (n = 13) and prefrontal cortex (n = 15). Analysis was carried out using Pearson1 or Spearman2 correlations. Correlations between elements of the monoamine pathway are shown in the table. Significant associations are indicated in bold. The double line black arrows show an inverse association and the single line black arrows a direct association between elements of the different pathways and general PANSS subscale scores (continued arrows p < 0.05; discontinued arrows p < 0.1)

Back to article page