Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Brain profiling in murine colitis and human epilepsy reveals neutrophils and TNFα as mediators of neuronal hyperexcitability

Fig. 1

Acute and chronic colitis cause a sustained reduction in seizure threshold. Experimental protocols for a acute and chronic DSS-induced colitis, b 30 days following acute DSS-induced colitis, and c TCT-induced colitis. d–f Latencies to seizure onset (left) and generalization (right) following flurothyl administration in mice with acute or chronic DSS-induced colitis (d), mice with TCT-induced colitis (e), and mice 30 days following initiation of acute DSS treatment (f). Data represent the combined analysis of three experiments containing 5–10 mice/condition/experiment. **p < 0.01, ***p < 0.001, ****p < 0.0001

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094