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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury

Fig. 3

Coefficients of linear mixed effect models, displayed as heatmaps. The colours of the heatmaps are graded such that red represents positive coefficients and blue represents negative coefficients. All coefficients are normalized using the quotient of their standard deviation and that of the dependent variable. Significant coefficients are highlighted with an asterisk. Independent variables are along the y-axis and the dependent variable for each model is the cytokine of the respective row on the x-axis in either A the brain extracellular fluid or B arterial blood. Differences in cytokines displayed between the two subfigures are due to insufficient data to generate all coefficients from the model. EGF epidermal growth factor, FGF.2 basic fibroblast growth factor, FLT.3.ligand Fms-related tyrosine kinase 3 ligand, G.CSF granulocyte colony stimulating factor, GM.CSF granulocyte-monocyte colony stimulating factor, IFNa2 interferon alpha-2, IFNg interferon gamma, IL interleukin, IL-1R interleukin 1 receptor, IL1ra interleukin-1 receptor antagonist, IL12p40 interleukin 12 subunit beta, IL12p70 interleukin-12, IP10 chemokine (C-X-C motif) ligand 10, MCP monocyte chemotactic protein, MDC macrophage-derived chemoattractant, MIP1a macrophage inflammatory protein-1alpha, MIP1b macrophage inflammatory protein-1beta, PDGF platelet-derived growth factor, RANTES chemokine (C-C motif) ligand 5, sCD40L soluble CD40 ligand, sIL.2R soluble interleuking-2 receptor, TGFa transforming growth factor alpha, TNFa tumour necrosis factor alpha, TNFb tumour necrosis factor beta, VEGF vascular endothelial growth factor

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