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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder

Fig. 6

Tregs reduced the expression of chemokines and pro-inflammatory cytokines. A Quantitative RT-PCR analysis of CCL1, CCL2, CCL5, TNF-α, IL-6, IFN-γ, IL-1β, and IL-10 expression 7 days after NMOSD induction. n = 4–5 mice for each group. *p < 0.05, **p < 0.01, ***p < 0.001, #p < 0.0001. ns, no significance, versus NMOSD group; statistical analyses were performed by one-way analysis of variance followed by Dunnett’s post hoc test. B Representative western blots of TNF-α and TGF-β1. C Quantitative analysis of TNF-α and TGF-β1 expression. n = 5 mice for each group. *p < 0.05, **p < 0.01, ***p < 0.001, #p < 0.0001. ns, no significance, versus NMOSD group; statistical analyses were performed by one-way analysis of variance followed by Dunnett’s post hoc test. D Representative Western blots of total protein and phosphorylated STAT3 from the NMOSD lesion. E Quantitative analysis of p-STAT3 relative to β-actin and STAT3 relative to β-actin. n = 7–8 mice for each group. *p < 0.05, ***p < 0.001, ns, no significance, versus NMOSD group; statistical analyses were performed by one-way analysis of variance followed by Dunnett’s post hoc test

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