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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Inhibition of microglial β-glucocerebrosidase hampers the microglia-mediated antioxidant and protective response in neurons

Fig. 2

Nfe2l2 activation in nigral dopaminergic neurons. Wild-type mice (C57BL/6 strain, n = 4/group) were treated as reported in Fig. 1A. A Representative confocal images of the substantia nigra pars compacta. Midbrain sections immunostained with anti-Nfe2l2 (red) and anti-Tyrosine hydroxylase (Th) (green) antibodies. Scalebar, 10 μm. B Semi-quantitative analysis of Nfe2l2-associated fluorescence in the nuclei of nigral dopaminergic neurons. Data are expressed as fold changes (FC) relative to the control value and presented as mean ± SEM. Statistical significance was determined by one-way ANOVA followed by Tukey’s post hoc test. ***p<0.001

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