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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Inhibition of microglial β-glucocerebrosidase hampers the microglia-mediated antioxidant and protective response in neurons

Fig. 6

GCase inhibition hampers neuroprotective functions of microglia. Flow cytometry analyses of propidium iodide fluorescence in: A SK-N-BE treated with 0.5 mM MPP+ or vehicle for 24 h, B SK-N-BE cultured alone or in coculture with BV-2 and treated with 0.5 mM MPP+, C cocultures treated with 200 μM CBE for 48 h or D with 200 μM CBE for 48 h and 0.5 mM MPP+ for 24 h. Data are expressed as fold changes (FC) versus vehicle treated samples (A, C, D) or monoculture sample (B), and presented as violin-plots with median (dash line) and quartiles (dot lines) of n=6 independent samples measured in triplicate.*p<0.05, ***p<0.001 calculated by unpaired t-test

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