Fig. 1

Inflammatory response and the modulation of HDAC expression by LPS in RT4 SCs. A Secretion of TNFα after LPS induction for 24 h were measured by ELISA. B Representative western blot data of changes in the expression of TNFα, c-PARP, and TLR4 expression in a dose-dependent manner, following LPS induction for 24 h. C Expression profile of HDAC1, 2, 3, and 4 after LPS induction for 24 h. D LPS-induced increases of HDAC3 activity were confirmed by HDAC3 activities assay. n = 4. Significance was assessed by one-way ANOVA. The data are presented as the mean ± SEM. *p < 0.05 versus 0 μg/ml LPS. LPS lipopolysaccharide, SCs Schwann cells, TNFα tumor necrosis factor α, c-PARP cleaved poly (ADP) ribose polymerase, HDAC histone deacetylase, TLR4 toll-like receptor 4, ANOVA analysis of variance, SEM standard error of the mean