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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NFκB to promote axonal regeneration and remyelination

Fig. 3

PBA prevents the LPS-induced NFκB-p65 phosphorylation and translocation to the nucleus. A Western blot analysis and quantification showing a significant decrease in phosphorylation of NFκB-p65 following combined PBA and LPS treatment. n = 4. B Reduction of activated NFκB-p65 into the nucleus was revealed after PBA treatment. C Immunofluorescence staining shows the reduced nuclear translocation of NFκB-p65 after induction with LPS and PBA together and its representative graph. n = 4. Significance was assessed by one-way ANOVA. Data are presented as the mean ± SEM. *p < 0.05 versus no LPS and no PBA. #p < 0.05 versus only LPS. PBA sodium phenylbutyrate, LPS lipopolysaccharide, NFκB-p65 nuclear factor κB p65 subunit, ANOVA analysis of variance, SEM standard error of the mean

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Journal of Neuroinflammation

ISSN: 1742-2094