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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: HMGB1 mediates cognitive impairment caused by the NLRP3 inflammasome in the late stage of traumatic brain injury

Fig. 1

The NLRP3 inflammasome is activated in the hippocampus–prefrontal cortex circuit 4 weeks to 8 weeks post-TBI. A–D Immunofluorescence revealed that NLRP3 (A–B) and caspase-1 (C–D) were significantly activated in the hippocampal DG, CA1, and CA3 and the prefrontal cortex at 4 weeks and 8 weeks post-TBI. Data represent the means ± SD (n = 5 mice per group). Representative protein bands showing NLRP3, ASC, pro-caspase-1, and caspase-1 (P20) expression in the hippocampus (E) and prefrontal cortex (F). G–H Western blot analysis indicating the level of the NLRP3 inflammasome in the hippocampus and prefrontal cortex. Each experiment was repeated three times. Data were normalized to Sham group data and are presented as the means ± SD (n = 3 mice per group). 2-way ANOVA, *p < 0.05, **p < 0.01, ***p < 0.001, compared to the Sham group

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