Fig. 2

NLRP3 knockout improves cognitive performance in the late stage of TBI. A Schematic representation of the method and process for the new object recognition (NOR) test. B Representative heatmap results for the NOR test indicating better short-term memory of NLRP3 knockout mice than wild-type mice. C–D Discrimination index of wild-type and NLRP3 knockout mice in the NOR test at 4 weeks and 8 weeks post-TBI, Unpaired t-test. D Schematic representation of the apparatus used in the T-maze test. E Alternation rate (%) in the T-maze test indicating that NLRP3 knockout attenuated working memory impairment at 4 weeks and 8 weeks post-TBI,2-way ANOVA. F Representative results of the nest-building assay. Complete rate (%) (G) and score (H) indicating that NLRP3 knockout attenuated social behavior at 4 weeks and 8 weeks post-TBI, unpaired t-test. Data represent the means ± SD (n = 10 mice per group). **p < 0.01, ***p < 0.001, ****p < 0.0001 compared to the WT group