Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system

Fig. 1

In vitro activity of CYR119. A GloSensor® luciferase assay in HEK293 cells in the presence of 0 to 30 µM DETA-NONOate. B, C Effect of CYR119 on cGMP and CREB phosphorylation in rat primary neurons. Representative concentration response of CYR119 as measured by cellular phosphorylation of CREB in the presence of 10 µM DETA-NONOate in rat primary neurons. Data are normalized to vehicle-control wells. EC50s are noted in each figure

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094