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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease

Fig. 3

Dendritic spine density and morphology in the hippocampus of WT, FAAH−/−, 5xFAD, and 5xFAD/FAAH−/− mice. A Deconvoluted confocal images of apical dendrites from DiI-labelled CA1 pyramidal neurons in 6-month-old WT, FAHH−/−, 5xFAD, and 5xFAD/FAAH−/− mice. Yellow arrows point to mushroom spines. B The dendritic spine density was determined in all four genotypes using the Neuron Studio freeware. Two-way ANOVA followed by Tukey’s test was used to determine differences among groups (**p < 0.01, ***p < 0.001). C Density of each type of dendritic spine (stubby, thin, and mushroom) in apical dendrites of CA1 pyramidal neurons in 6-month-old WT, FAHH−/−, 5xFAD, and 5xFAD/FAAH−/− mice. Two-way ANOVA followed by Tukey’s test (*p < 0.05, **p < 0.01, ***p < 0.001). For all panels, data are presented as means ± s.e.m. (n = 21 dendrites per genotype from 3 to 4 mice per genotype)

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