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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia

Fig. 2

Echocardiograms and histology to confirm myocardial infarctions in the heart failure model. A Simpson Ejection Fraction was calculated using V-mode left ventricle calculations treatment groups: heart failure (HF)-A50 (Ang-(1–7)50 ug/kg), HF-P50 (PNA5 50ug/kg), HF-A500 (Ang-(1–7) 500 ug/kg), HF-P500 (PNA5 500 ug/kg), HF-Saline, Control-Saline. Significant difference between Control-Saline and the following treatment groups are as listed: HF-Saline, HF-A50 (Ang-(1–7)50 ug/kg), HF-P50 (PNA5 50 ug/kg), HF-A500 (Ang-(1–7)500 ug/kg), HF-P500 (PNA5 500 ug/kg), P < 0.05 ANOVA, Dunnett’s post. B Simpson End Systolic Volume was calculated using V-mode left ventricle calculation. Significant difference between Control-Saline and the following treatment groups are as listed: HF-Saline p = 0.001, HF-P50 (PNA5 50 ug/kg) p = 0.0001, and HF-A500 (Ang-(1–7)500 ug/kg) p = 0.015, ANOVA, Dunnett’s post. C Examples of hematoxylin and eosin staining of paraffin embedded formalin fixed hearts demonstrates differences in wall morphology between Control animals and HF-saline, PNA5, and Ang-(1–7) treatment mice. Left ventricle wall is indicated with black arrow. Images were taken at 5 × magnification

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