Fig. 4

Treatment with Ang-(1–7)/Mas R agonists decreases plasma NfL levels. A Data are represented with mean and ± SE. Compares NfL levels between control saline and HF-saline mice, p = 0.08, Welch’s t-test. This difference did not reach significance. B PNA5 at 50ug/kg and Ang-(1–7) at 50 ug/kg, and 500 ug/kg significantly reduced NfL plasma concentration in VCID mice compared to HF-saline treated mice, Kruskal–Wallis ANOVA, Dunn’s post, p < 0.05. C NfL plasma levels significantly negatively correlated with Discrimination ratios. Correlation R values were produced using Pearson’s correlation analysis and the fit line was determined using simple linear regression