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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia

Fig. 5

Increased TNFα in VCID models are inhibited by PNA5 and Ang-(1–7). Plasma TNFα of Control-Saline, HF-Saline, HF-A50 (Ang-(1–7)50 ug/kg), HF-P50 (PNA5 50ug/kg), HF-A500 (Ang-(1–7)500ug/kg), HF-P500 (PNA5 500ug/kg), were measured via MILLIPLEX MAP Mouse High Sensitivity Multiplex Immunoassay. Significance were observed between HF-Saline vs Control-Saline treated mice (3.50± SE 0.15, n = 6 vs mean 3.12, ± SE 0.01, n = 6, respectively, p = 0.003;), PNA5, and Ang-(1–7) (HF-P50 mean 3.12 pg/mL± SE 0.00, n = 5 p = 0.004; HF-A50 mean 3.12 pg/mL± SE 0.00, n = 6, p = 0.003; HF-P500 mean 3.12 pg/mL± SE 0.00, n = 6, p = 0.003; ANOVA, Dunnett’s post; values that were at or below assay threshold of 3.12 pg/mL were represented as 3.12 pg/mL)

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