Fig. 6

Effect of treatment with Ang-(1–7)/MasR agonists on brain cytokine levels. Whole brain lysate cytokine levels were measured using MILLIPLEX MAP Mouse High Sensitivity Multiplex Immunoassay. A–F HF-Saline treated VCID mice had significantly lower IL-1α, IL-2, IL-17, and IP-10 levels in comparison to Control-Saline treated mice. PNA5 and Ang-(1–7) significantly increased cytokines levels as compared to HF-saline treated animals. Data are represented with mean and ± SE. Differences in groups were tested by ANOVA, Dunnett’s post hoc, significance set a p < 0.05