Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia

Table 3 Longitudinal values of HF-induced inflammation comparing plasma cytokines at 3 weeks post-MI to 8 weeks post-MI

	Cytokine and chemokine, relative expression				p values
	3 weeks HF	3 weeks HF	8 weeks HF	8 weeks HF	3 weeks Control-Saline vs. 3 weeks HF-Saline	3 weeks Control-Saline vs. 3 weeks HF-Saline	3 weeks HF-Saline vs. 8 weeks HF-Saline
Cytokines	Control-Saline (n=5)	HF-Saline (n=7)	Control-Saline (n=6)	HF-Saline (n=6)	3 weeks Control-Saline vs. 3 weeks HF-Saline	3 weeks Control-Saline vs. 3 weeks HF-Saline	3 weeks HF-Saline vs. 8 weeks HF-Saline
IL-1α	176.1 ± 34.8	882.3 ±198.4	92.8 ± 5.9	74.7 ±5.4	0.003*	0.964	0.0004*
MIP-1α	32.6 ±9.7	67.9 ±6.6	6.8 ± 1.2	6.4 ±1.3	0.002*	0.027*	<0.0001*
MIP-2	65.0 ±11.4	155.9 ±17.0	45.2 ±6.3	54.1 ±14.7	0.0009*	0.764	0.0001*

Mean, Standard error, and number of sample values of plasma IL-1α, MIP-1α, and MIP-2 from 3 and 8 weeks post-MI are represented for both treatment groups Control-Saline, and HF-Saline. P values of the following comparison are provided: 3 weeks post-MI Control-Saline and 3 weeks post-MI HF-Saline, 3 weeks post-MI Control-Saline and 8 weeks post-MI Control-Saline, and 3 weeks post-MI HF-Saline and 8 weeks post-MI HF-Saline. *Indicates significance, p < 0.05, (ANOVA, Tukey’s post), ns not significant

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