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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury

Fig. 5

Ganglionic macrophages in sensory ganglia after nerve injury are categorized to “tissue repair”. CD206-positive cells (green) (a), multiple staining showing co-localization (arrowhead) of CD206 signals (green) with Iba1-positive cells (red) (b), and the number of CD206- and Iba1-positive cells (n = 4/group) (c) in contralateral (contra) and ipsilateral (ipsi) sides of the maxillary nerve region of the trigeminal ganglion on day 7 after infraorbital nerve ligation. CD86-positive cells (green) (d), multiple staining showing co-localization (arrowhead) of CD86 signals (green) with Iba1-positive cells (red) (e), and the number of CD86- and Iba1-positive cells (n = 4/group) (f) on day 7 after infraorbital nerve ligation. Caspase-3-positive cells (brown, arrowhead) on weeks 1 and 4 after nerve ligation (g) and the number of caspase-3-positive cells (n = 4/timepoint) (h). Caspase-3 (green)- and PGP9.5 (red)-positive cells (i) and the percentage of caspase-3-positive neurons (n = 129 cells/ipsi from 4 mice) (j) on day 7 after nerve ligation. See list of abbreviations. Scale bars are indicated. Data are represented as mean (S.D.), and differences were detected using Student’s t test (c), Student’s t test with Welch’s correction (f), and one-way ANOVA with Tukey–Kramer test (h)

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