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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Inhibition of vascular adhesion protein 1 protects dopamine neurons from the effects of acute inflammation and restores habit learning in the striatum

Fig. 3

VAP-1 inhibition reduces the inflammatory response in the striatum. AD Immunostaining for Iba1 cells in the striatum at 24 h. E Quantification of Iba1-positive area in the ipsilateral striatum (LPS) and contralateral striatum (CTR) at 24 h after injection of LPS in the SN. LPS–Vehicle (n = 7), LPS–PXS-4681A (n = 5). F Iba1-positive area in the striatum at 2 weeks. Values represent the mean ± SEM. LPS–Vehicle (n = 10); LPS–PXS4681A (n = 11). G Iba1-positive cell count in the striatum at 24 h after LPS insult. Values represent the mean ± SEM. H Iba1-positive cell count in the striatum at 2 weeks. Values represent the mean ± SEM. IK Quantification of TNF-alpha, IL-1beta and IL-10 levels in the striatum at 24 h. Values represent the mean ± SEM. LPS–Vehicle (n = 7), LPS–PXS-4681A (n = 5). L Quantification of GFAP-positive area in the dorsal striatum 24 h. LPS–Vehicle (n = 7), LPS–PXS-4681A (n = 5). MP Immunostaining for GFAP in the dorsal striatum. *p < 0.05; **p < 0.01, ***p < 0.001

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