Fig. 3

VAP-1 inhibition reduces the inflammatory response in the striatum. A–D Immunostaining for Iba1 cells in the striatum at 24 h. E Quantification of Iba1-positive area in the ipsilateral striatum (LPS) and contralateral striatum (CTR) at 24 h after injection of LPS in the SN. LPS–Vehicle (n = 7), LPS–PXS-4681A (n = 5). F Iba1-positive area in the striatum at 2 weeks. Values represent the mean ± SEM. LPS–Vehicle (n = 10); LPS–PXS4681A (n = 11). G Iba1-positive cell count in the striatum at 24 h after LPS insult. Values represent the mean ± SEM. H Iba1-positive cell count in the striatum at 2 weeks. Values represent the mean ± SEM. I–K Quantification of TNF-alpha, IL-1beta and IL-10 levels in the striatum at 24 h. Values represent the mean ± SEM. LPS–Vehicle (n = 7), LPS–PXS-4681A (n = 5). L Quantification of GFAP-positive area in the dorsal striatum 24 h. LPS–Vehicle (n = 7), LPS–PXS-4681A (n = 5). M–P Immunostaining for GFAP in the dorsal striatum. *p < 0.05; **p < 0.01, ***p < 0.001