Fig. 4

VAP-1 inhibition reverses the deficit in habitual motor learning. A LPS infusion. B Behavioural task. C–C’ TH-immunoreactivity in the striatum C and in the SN C’) for the LPS-injected animals. D Lever pressing rate during training. Saline (n = 16), LPS–Vehicle (n = 21), LPS–PXS-4681A (n = 17). E Extinction test. The mean percentage as compared to baseline lever press rate for the devalued and the valued groups is shown. Saline–Vehicle devalued (n = 8), valued (n = 8); LPS–Vehicle devalued (n = 10), valued (n = 11); LPS–PXS-4681A devalued (n = 8), valued (n = 9). F Consumption test on day 3 of taste aversion devaluation. G Grip Strength Meter. H Rotarod performance. I Average of lever press rate of the two outcomes during training. Saline–Vehicle (n = 6); LPS–Vehicle (n = 6); LPS–PXS-4681A (n = 6). J Mean lever press rate during extinction test after specific satiety devaluation. Values represent the mean ± SEM. *p < 0.05; **p < 0.01, ***p < 0.001