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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic–ischemic injury in rats

Fig. 2

Effect of intranasal administration of TC-G 1008 on brain infarct are, short-term neurological function and body weight at 48-h post-HIE. (A-B) TTC staining showed that low (5 mg/kg) and medium (15 mg/kg) doses of TC-G 1008 significantly reduced infarct area when compared with vehicle. C–D Righting reflex and geotaxis reflex showed that middle dose (15 mg/kg) of TC-G 1008 significantly improved neurological function compared to vehicle animals. E TC-G 1008 significantly reduced HIE-induced body weight loss of rat pups. (Data are represented as mean ± SD; *p < 0.05 vs. sham; #p < 0.05 vs. HIE + vehicle, n = 6/group)

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Journal of Neuroinflammation

ISSN: 1742-2094