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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic–ischemic injury in rats

Fig. 8

SIRT1 inhibitor EX527 abolished the anti-inflammatory effects of TC-G 1008 via GPR39/SIRT1/PGC-1α/Nrf2 signaling pathway at 48-h post-HIE. A Representative western blot bands. BH Densitometric quantification of GPR39, SIRT1, PGC-1α, Nrf2, IL-1β, IL-6 and TNF-α in the ipsilateral hemisphere showed that EX527 significantly abolished the effects of TC-G 1008 treatment, resulting in a decrease in PGC-1α and Nrf2 expression, and an increase in IL-6, IL-1β and TNF-α expression.*p < 0.05 vs. sham; #p < 0.05 vs. HIE + vehicle; @p < 0.05 vs. HIE + TC-G1008 + control CRISPR, data are represented as mean ± SD, n = 6 for each group

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