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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Functional role of brain-engrafted macrophages against brain injuries

Fig. 6

BEMs protects against concussive injury-induced memory deficits. a Schematic of experimental design for concussive injury, cognitive test and following analyses. b Dot plot to show the result of in vivo phagocytosis assay by FACS after injection of pre-stained synaptosomes, each dot represents value from an individual mouse, n = 4–5. c Dot plot showing result of in vivo phagocytosis assay by IF imaging and quantification, each dot represents mean counts from an individual mouse, n = 3. d Representative images showing microglia and BEMs (arrows) phagocytosing injected synaptosomes (green dots). e Sholl analysis result showing numbers of intersections at different distances to the cell center, n = 5–6. f Dot plot showing NOR test result, each dot represent the performance of an individual mouse, n = 12. Statistical analyses were performed using two-way ANOVA with Tukey’s multiple comparisons test (b and c) for each distance point (e) or unpaired t-test (f). *p < 0.05, **p < 0.01, ***p < 0.001

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