Fig.10

Dynamic changes in inflammation after long-term LM11A-31 treatment on days 7, 14 and 28. a Representative H&E staining of coronal brain sections from each group on days 7, 14 and 28. Scale bar = 50 μm. b Western blot analysis of p75NTR protein level in the hippocampus on days 7 and 28. Proteins were normalized to β-actin. c–e Relative mRNA expression of proinflammatory cytokines/mediators (IL-1β, TNF-α, IL-6 and iNOS) in the hippocampus on days 7, 14 and 28. Quantification of mRNA level expression was normalized to β-actin. Data are presented as the mean ± SEM (n = 4 rats). ns non-significant, *p < 0.05, **p < 0.01, ***p < 0.001