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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Regulation of the p75 neurotrophin receptor attenuates neuroinflammation and stimulates hippocampal neurogenesis in experimental Streptococcus pneumoniae meningitis

Fig. 5

LM11A-31 pretreatment ameliorates neuronal apoptosis and necrosis at 24 h after PM induction. a Immunofluorescent staining showing apoptotic neurons assessed by TUNEL staining in the hippocampal DG. Scale bar = 100 μm. b Representative images showing degenerating neurons indicated by FluoroJdeB (FJB) staining in the cortex and hippocampal DG. Scale bar = 50 μm. c Quantification of TUNEL-positive cells in the hippocampal DG. d Quantification of FJB-positive degenerating cells/200× fields in the cortex and hippocampus. Data are presented as the mean ± SEM (n = 4–5 rats). **p < 0.01, ***p < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094