Fig. 8

p75NTR knockdown reduces PM-induced brain injury. Ad-shp75NTR-mediated knockdown of p75NTR. One week after virus infusion, all rats were inoculated with S. pneumoniae in the lateral ventricle. a, b p75NTR protein levels in the cortex and hippocampus were measured by Western blot analysis 24 h post-infection. c Representative images of the sections with inflammatory cells in the cavum subarachnoidale. Scale bar = 100 μm. d, e Western blot analysis of inflammation-related transcription factors in the cortex and hippocampus from rats treated with shp75NTR or shSCR at 24 h after PM induction. Data are presented as the mean ± SEM (n = 5 rats). *p < 0.05, **p < 0.01