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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Blockade of the NLRP3/caspase-1 axis attenuates ketamine-induced hippocampus pyroptosis and cognitive impairment in neonatal rats

Fig. 2

Effect of inhibition of NLRP3/Caspase-1 axis on ketamine-induced pyroptosis in hippocampus of neonatal rats. A Protein bands and quantitative analysis of NLRP3-3, ASC, cleaved Caspase-1, and cleaved GSDMD (n = 3). B TUNEL staining in hippocampus and the number of positive cell, Scale bar 50 μm. C Cytokines levels of IL-1β and IL-18 in hippocampus (n = 6). Values are expressed as the mean ± SD. *P < 0.05, **P < 0.01, compared with group C; # P < 0.05, ##P < 0.01, compared with group Ket. Con, control; Ket, ketamine

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