Fig. 4
From: T-cell dysregulation is associated with disease severity in Parkinson’s Disease
Increased activation of PD T cells by PHA is associated with disease progression. A, B CD3+ T cells were enriched from peripheral blood, stimulated with PHA and T-cell activation assayed by quantitation of CD69 expression on the cell surface. Activation was slightly increased in PD patients’ T cells [HC (n = 14, f/m = 6/8) and PD patients (n = 23, 6/17 f/m), p < 0.09, two-way ANOVA: case p < 0.10, sex p > 0.99, age p < 0.16]. C Correlation of T-cell activation with PD clinical traits (Spearman’s ρ). D T-cell activation is significantly increased in PD patients with advanced disease progression (H&Y ≥ 3. two-way ANOVA: H&Y *p < 0.05, sex p > 0.25, age p > 0.51). Boxplots: median ± interquartile range; *p < 0.05, Mann–Whitney U test, two-way ANOVA