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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: MicroRNA-204-5p reduction in rat hippocampus contributes to stress-induced pathology via targeting RGS12 signaling pathway

Fig. 3

Effects of changes in miR-204-5p expression within the hippocampal DG region of normal and CUS rats. A Schematics of AAV vectors engineered to overexpress miR-204-5p, knock-down miR-204-5p and their corresponding controls. B Experimental paradigm for determining behavioral responses of rats infected with the virus. C Illustration of AAV viral infusion into the DG region. Scale bar is 1 mm. D The infection efficiency of AAV-miR-204-5p sponge and AAV-miR-204. Expression level of miR-204-5p in the DG region infected with AAV-204-5p or AAV-204-5p sponge (N = 10 per group). Behavioral responses in the (E) FST (N = 20 per group), (F) SPT (N = 20 per group) and (G) MWM of rats expressing various viral constructs within the DG region (N = 6 per group). *P < 0.05, **P < 0.01 ***P < 0.001, ****P < 0.0001, control + AAV-control vs control + AAV-miR-204-5p sponge; &P < 0.05, &&P < 0.01, &&&P < 0.001, &&&&P < 0.0001, CUS + AAV-control vs CUS + AAV-miR-204-5p. Data are presented as means ± SEMs. Student t-tests were employed for comparisons between the two groups. One-way ANOVA followed by Tukey’s post-hoc test was used for D. Two-way ANOVA was used for EF

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