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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NF-κB/STAT3 signaling pathway

Fig. 1

Schematic illustration of the experimental design. a Timeline of WT mice that underwent sham surgery or CLP. b Timeline of WT or CXCR5−/− mice that underwent sham surgery or CLP. c Timeline of LPS-treated microglial cells treated with CXCR5 siRNA with or without pretreatment with the p38MAPK inhibitor SB203580 or agonist P79350. d Timeline of LPS-treated microglial cells treated with CXCR5 siRNA with or without pretreatment with the autophagy inhibitor 3-MA or agonist rapamycin. CLP cecal ligation and puncture, CXCR5 C-X-C chemokine receptor type 5, LPS lipopolysaccharide, siRNA short interfering RNA, 3-MA 3-methyladenine, WT wild-type

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Journal of Neuroinflammation

ISSN: 1742-2094