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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NF-κB/STAT3 signaling pathway

Fig. 6

CXCR5 knockout decreased hippocampal p-p38MAPK, IL-1β and IL-6 levels in mice with sepsis-associated encephalopathy. WT mice or mice lacking the CXCR5 gene (CXCR5−/−) were subjected to sham surgery or CLP. ad Western blot and densitometry of hippocampal p-p38MAPK, p38MAPK, IL-1β and IL-6 (n = 4 per group). *p < 0.05 vs. WT + sham; #p < 0.05 vs. WT + CLP. CLP cecal ligation and puncture, CXCR5 C-X-C chemokine receptor type 5, IL-1β interleukin (IL)-1β, IL-6 interleukin (IL)-6, p38MAPK mitogen-activated protein kinase, p-p38MAPK phosphorylated p38MAPK, WT wild-type

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