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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NF-κB/STAT3 signaling pathway

Fig. 8

CXCR5 knockdown reversed the alteration of p38MAPK-dependent microglial M1/M2 polarization and production of inflammatory cytokines in LPS-treated microglial cultures. a Representative micrographs of immunohistochemistry for Iba-1 in the microglia. Magnification, 200 × . Scale bar, 100 μm. b Calculation of Iba-1-positive area. c–h Western blot and densitometry of Iba-1, CD86, CD206, IL-1β and IL-6 (n = 4 per group). *p < 0.05 vs. control; #p < 0.05 vs. LPS; &P < 0.05 vs. LPS + CXCR5 siRNA. GAPDH glyceraldehyde-3-phosphate dehydrogenase, Iba-1 ionized calcium binding adaptor molecule-1, IL-1β interleukin-1β, IL-6 interleukin-6, LPS lipopolysaccharide

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Journal of Neuroinflammation

ISSN: 1742-2094