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Table 1 Statistical analysis of DRG and neuroblastoma neurons ICC, and monkey peripheral nerve IHC

From: Autoantibody screening in Guillain–Barré syndrome

 

GBS patients (n = 100)

Controls (n = 90/56)

p value

Any reactivity

Strong reactivity

Any reactivity

Strong reactivity

Any reactivity

Strong reactivity

Neuroblastoma neurons IgG

11 (11%)

2 (2%)

10/90 (11.1%)

0/90 (0.0%)

 > 0.999 (ns)

0.499 (ns)

Neuroblastoma neurons IgM

28 (28%)

8 (8%)

11/90 (12.2%)

2/90 (2.2%)

0.011 (*)

0.105 (ns)

DRG neurons IgG

32 (32%)

6 (6%)

6/90 (6.7%)

0/90 (0.0%)

 < 0.0001 (***)

0.030 (*)

DRG neurons IgM

34 (34%)

11 (11%)

22/90 (24.4%)

2/90 (2.2%)

0.156 (ns)

0.020 (*)

Monkey peripheral nerve IgG

56 (56%)

17 (17%)

30/56 (53.6%)

3/56 (5.4%)

0.8669 (ns)

0.0455 (*)

Monkey peripheral nerve IgM

44 (44%)

10 (10%)

20/56 (35.7%)

6/56 (10.7%)

0.3964 (ns)

 > 0.999 (ns)

  1. Comparison between GBS patients and controls. Strong reactivity includes scores 2 and 3, and any reactivity includes scores 1, 2 and 3. Fluorescence intensity scores were analysed using contingency analysis with the application of a Fisher’s exact test, accepting an alpha-level of < 0.05 to determine significance