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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Brain transcriptome analysis of a CLN2 mouse model as a function of disease progression

Fig. 1

Volcano plot. Representation of differentially expressed genes (FDR ≤ 0.1 and fold-change ≥ 1.5) at 2-, 3- and 4-month-old cerebellum (Cb) and fore- and mid-brain (F/M) regions between Tpp1−/− and control animals. Selected downregulated genes (blue dots) and upregulated genes (red dots) are designated. The rest of the genes are represented with gray open circles. Tpp1 levels are indicated with a circle. For one-month-old animals the −log10 of the p value was represented instead. For this data set, Tpp1 and Trim 12a (rectangle) were found to be significantly downregulated

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