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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Brain transcriptome analysis of a CLN2 mouse model as a function of disease progression

Fig. 2

Heatmap with clustering of cell-type specific DEG in Tpp1−/− brain regions as a function of time. Distribution of cell-type specific genes that are commonly enriched in DEG from Cb-T vs. Cb-N (green) and F/M-T vs. F/M-N (blue) comparisons at 1, 2, 3, 4 months (different degrees of reds). Gene expression ratios (FPKM T/ average FPKM N) are represented in logarithmic scale. Cell-type A microglia, B astrocytes and C neurons) specificity of DEG was established from data imputed from Zhang et al. [49] based on genes that were exclusively expressed in each cell type and had FPKM expression values at least five times higher than in the rest of the other cell types. Choroid plexus genes (D) where classified by expression values from Turner et al., 2014 [53]

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