Fig. 3
From: Brain transcriptome analysis of a CLN2 mouse model as a function of disease progression
Ingenuity pathways analysis (IPA). DEG found in Tpp1−/− vs control mouse cerebellum (Cb) and fore- and mid-brain (F/M) regions were used in the analysis. Selected canonical pathways were identified using IPA gene ontology algorithms for F/M and Cb areas scored as − log(p-value) from Fisher’s exact test, set here to a threshold of 1.25. The ratio (red dots connected by a line) indicates the ratio of genes from the data set that map to the pathway divided by the total number of genes that map to the same pathway. For a complete list of canonical pathways and genes involved, see Additional file 5