Fig. 5From: Brain transcriptome analysis of a CLN2 mouse model as a function of disease progressionIncrease in choroid plexus gene expression in Tpp1−/− brains. A Relative transcript expression of 5 genes upregulated in Tpp1−/− choroid plexus were quantified by qPCR in independent F/M RNA extractions, performed in triplicate. Relative normalized expression values were determined from the ΔΔCt for the indicated target genes relative to Ppia (peptidylprolyl isomerase A) expression in control brains (wt). *p < 0.001; B Expression pattern of Lipopolysaccharide binding protein and Klotho (blue staining) in the lateral and 4th ventricle of Tpp1−/− and control choroid plexus detected by mRNA in situ hybridizationBack to article page