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Table 1 Summary of differentially expresses genes resulting from RNA-seq comparisons of cerebellum (Cb) and fore- and mid-brain (F/M) regions between Tpp1−/− (T) and control animals (C) at different ages

From: Brain transcriptome analysis of a CLN2 mouse model as a function of disease progression

Month % of reads mapped Mouse gene analyzed Brain region DEG
T vs C
DEG down
T vs C
DEG up
T vs C
1* 88.7 14,681 F/M 2 (126) 2 (84) 0 (42)
Cb 2 (255) 2 (65) 0 (190)
2 87.2 14,081 F/M 139 25 114
Cb 339 292 47
3 88.1 14,575 F/M 89 11 78
Cb 154 31 123
4 88.3 14,923 F/M 510 171 339
Cb 1550 553 1071
  1. *At 1 month few DEGs genes were detected using FDR-corrected p-values; raw p-values were considered instead in the threshold (p < 0.1) only at 1-month-old (number in parenthesis)