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Table 1 Summary of differentially expresses genes resulting from RNA-seq comparisons of cerebellum (Cb) and fore- and mid-brain (F/M) regions between Tpp1−/− (T) and control animals (C) at different ages

From: Brain transcriptome analysis of a CLN2 mouse model as a function of disease progression

Month

% of reads mapped

Mouse gene analyzed

Brain region

DEG

T vs C

DEG down

T vs C

DEG up

T vs C

1*

88.7

14,681

F/M

2 (126)

2 (84)

0 (42)

Cb

2 (255)

2 (65)

0 (190)

2

87.2

14,081

F/M

139

25

114

Cb

339

292

47

3

88.1

14,575

F/M

89

11

78

Cb

154

31

123

4

88.3

14,923

F/M

510

171

339

Cb

1550

553

1071

  1. *At 1 month few DEGs genes were detected using FDR-corrected p-values; raw p-values were considered instead in the threshold (p < 0.1) only at 1-month-old (number in parenthesis)