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Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: Interleukin-6 mediates delirium-like phenotypes in a murine model of urinary tract infection

Fig. 11

Western blot confirms immunohistological CC3 findings and plasma IL-6 levels positively correlate with cortical CC3. a Quantification (upper panel) and representative western blot images (lower panel) of cortical CC3 levels shows significant increases in UTI mice treated with saline (p < 0.001) (ANOVA, F = 85.28, dF = 22, p < 0.0001) and significant reduction of cortical CC3 in UTI mice treated with the anti-IL-6 antibody compared to the control group (p < 0.05) (ANOVA, F = 10.75, dF = 27, p = 0.0004). Each dot represents one animal (n = 10 in control, n = 10 in UTI, n = 8 in UTI + α-IL-6). b Plasma IL-6 levels measured via ELISA shows UTI and UTI + α-IL-6 group had significantly increased plasma IL-6 compared to the control group (n = 5 in control, n = 10 in UTI, n = 8 in UTI + α-IL-6). Quantitative data are expressed in mean ± SD. c Positive significant correlation between plasma IL-6 and frontal CC3 for UTI mice and controls. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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