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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest

Fig. 8

Schematic representation of AIM2-induced neuroinflammation and CHMP2A-mediated autophagy in CA-ROSC. Ischemia/reperfusion injury activates the AIM2 inflammasome and decreases CHMP2A expression. Impaired autophagic flux caused by a reduction in CHMP2A damages AIM2 inflammasome degradation and then triggers excessive inflammation, including cellular pyroptosis, which in turn impairs autophagy. In addition, AIM2 knockdown alleviates neuroinflammation and enhances the autophagic process after OGD-Rep. CHMP2A overexpression inhibits neuroinflammation and improves neurologic outcomes in CA-ROSC

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Journal of Neuroinflammation

ISSN: 1742-2094