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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway

Fig. 6

TRPV4 activation enhances the expression of GFAP. A Immunofluorescence images show GFAP protein expression profiles in rat retinal vertical slices acquired from sham-operated retinas (saline-injected; control) (A1), 1 µM GSK101-injected retinas (A2), and 10 µM GSK101-injected retinas (A3). Retinas that received no GFAP antibody served as negative controls (A4). Double immunofluorescence staining showing GFAP expression when the GFAP antibody was pre-adsorbed with its blocking peptide (BP) (A5). Scale bar: 20 µm. B Representative immunoblots showing changes in GFAP protein levels in control and 10 µM GSK101-injected retinas. C Bar chart summarizing mean expression levels of GFAP under different conditions. n = 6. *p < 0.05 vs control

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Journal of Neuroinflammation

ISSN: 1742-2094