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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway

Fig. 8

TRPV4 activation enhances TNF-α production in retinal tissues. A Cumulative changes in TNF-α mRNA levels in saline-injected retinas (control) and retinas with GSK101 injection at 1 week. n = 5, *p < 0.05 vs control. B GSK101 treatment enhanced TNF-α protein levels in retinas with GSK101 injection at 1 week. C Bar chart summarizing mean expression levels of TNF-α under different conditions. n = 3. *p < 0.05. D Representative immunoblots showing changes in TNF-α protein levels in control and COH retinal extracts at G2w. E Bar chart summarizing mean expression levels of TNF-α under different conditions. n = 3. *p < 0.05. F Representative immunoblots showing changes in TNF-α protein levels in COH, and HC-067 plus COH retinas at 2 weeks after establishment of the COH model. G Bar chart summarizing mean expression levels of TNF-α under different conditions. n = 8. *p < 0.05

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Journal of Neuroinflammation

ISSN: 1742-2094