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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response

Fig. 4

Neutralization of IL-17A abolishes the worse outcome of Il10−/− mice. Triphenyltetrazolium chloride staining was used for evaluation of infarct volume at day 7 of IL-17A antibody (A) or IgG control (C) treated Il10−/− and WT control mice. Bederson score was performed 7 days after tMCAO IL-17A antibody (B) or in IgG control (D) treated group. Infarct data are presented as mean ± SEM of 9–11 WT and 6–9 Il10−/− mice per group. Bederson score as mean ± SEM of 9–11 WT and 7–10 Il10−/− mice per group. Statistical significances were analyzed by Student t test (A, C) and Mann–Whitney U test (B, D). *P < 0.05

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