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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response

Fig. 5

T cell-specific blockade of IL-10R leads to increased frequencies of IL-17A+ CD4+ and γδ T cells. Flow cytometric analysis of IL-17A produced by CD4+ (A) and γδ (B) T cells isolated from ischemic hemispheres of CD4CreIl10Rawt/wt controls and CD4CreIl10Rafl/fl 7 days after tMCAO. C Flow cytometric analysis of IL-10R (CD210) on IL-17A+ and IL-17A γδ T cells isolated from ischemic hemispheres of C57BL/6 mice 7 days after tMCAO. D Flow cytometric analysis of IL-17A produced by γδ T cells isolated from ischemic hemispheres of TCRδCreERIl10Rawt/wt controls and TCRδCreERIl10Rafl/fl 7 days after tMCAO. Flow cytometric data is represented as mean ± SEM of 9 CD4CreIl10Rawt/wt and 8 CD4CreIl10Rafl/fl (A, B), 6 WT (C) and 6 TCRδCreERIl10Rawt/wt and 7 TCRδCreERIl10Rafl/fl (D) mice per group. Statistical significances were analyzed by Student t test (AD). *P < 0.05, **P < 0.01. MFI mean fluorescent intensity

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