Fig. 6
From: Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response
Control of IL-17A production in γδ but not CD4+ T cells is dependent on IL-10R expression on Foxp3+ Tregs. A Flow cytometric analysis of the IL-10R (CD210) Mean Fluorescent Intensity (MFI) on Foxp3+ and Foxp3− CD4+ T cells in FIR-tiger mice. Flow cytometric analysis of IL-17A produced by CD4+ (B) and γδ (C) T cells isolated from ischemic hemispheres of Foxp3CreIl10Rawt/wt and Foxp3CreIl10Rafl/fl controls 7 days after tMCAO. (D) Proposed mechanism of protection from ischemic brain injury induced by IL-10. Flow cytometric data is presented as mean ± SEM of 6 FIR-tiger (A) and 6 Foxp3CreIl10Rawt/wt and 7 Foxp3CreIl10Rafl/fl mice per group (B, C). Statistical significances were analyzed by Student t test (A–C). **P < 0.01 and ***P < 0.01