Fig. 1

Mice with colitis exhibit inflammation in the colon. Male mice (white circles) and female mice (black circles) were treated with 2% DSS for 7 days. Body weight (A), colon lenghts (B) and caspase biosensor signal (C) were measured. Colon sections isolated from control and DSS mice were homogenized and inflammatory cytokine and chemokine levels were measured by CBA in control or DSS-treated male mice (D). CBA data are expressed as the log2FC in cytokine/chemokine expression, relative to the average cytokine/chemokine levels measured in control mice. Representative expression data from 5 mice in each group are shown (D). Fecal samples were isolated from control and DSS-treated mice and assessed for blood in the stool by Hemoccult (E). Representative colonic H&E sections from one control male and one DSS-treated male mouse (F). One-way ANOVA followed by a Bonferroni (95% CI, p < 0.05) multiple comparisons test (A, B). Student’s t test comparing DSS to respective control for each individual cytokine / chemokine (D). *** = p < 0.0005, ** = p < 0.005, * = p < 0.05